Smooth Muscle. Histology of the skeletal muscle - Title: PowerPoint Presentation Author: intel Last modified by: histo1 Created Date: 10/12/2001 7:04:18 AM Document presentation format: On … Poland sequence involves the absence of the pectoralis minor, partial absence of the pectoralis major, the absence or displacement of the nipple and areola, and the accompanying presence of digital defects. There are 3 types of muscle (skeletal, cardiac and smooth). Craniosynostosis involves the premature closure of one or more sutures of the skull. Formation of the cranial vault, most bones of the face, and the clavicle occur by intramembranous ossification, whereas formation of the rest of the axial and appendicular skeleton occur by endochondral ossification. The plasticity of skeletal muscle refers to its ability to adapt to environmental changes and its potential for regeneration. The nucleus becomes elongated, and myofilaments appear in the cytoplasm. by M te Pas, H Haagsman, M Everts September 2004 Well-developed and functional muscle tissues are a prerequisite for healthy meat-producing animals. Only at approximately 20 years of age are when the epiphyses and diaphysis fuse, indicating that skeletal growth is complete. Phocomelia (seal limb) involves the absence of long bones, resulting in rudimentary hands and feet attached to the trunk and pelvis. Muscle Development of Livestock Animals: Physiology, Genetics and Meat Quality. Explain the regular progression of follicular development and atresia occurring in a cyclic fashion in the primary ovary. Histology is the microscopic counterpart to gross anatomy, which looks at larger structures visible without a microscope. Accessory ribs are usually rudimentary and unilateral or bilateral; they develop from the costal processes of cervical or lumbar vertebrae. Mutations in MYH3, the gene encoding MyHC-emb, lead to Freeman–Sheldon and Sheldon–Hall congenital contracture syndromes. The bones that make up the skull thus form either by intramembranous ossification or endochondral ossification. Microscopic Anatomy of Skeletal Muscle Development of Skeletal Muscle Figure 10.2 Skeletal muscles are unique in that they are one of the few types of cells in our body which is multinucleated Single muscle fibers are formed from the fusion of embryonic myoblasts cells. This current page is a bookmark for muscle development related pages. Each myoblast retains its nucleus during fusion leading to mature muscle fibers However, this process only starts by the end of the embryonic period. In turn, the dermomyotome will differentiate into dermatome cells forming the dermis of the back and the neck, and myotome cells forming the skeletal muscles. All rights reserved. The skull can be divided in two parts: the neurocranium that forms a protective case around the brain, and the viscerocranium that forms the skeleton of the face. IFBB Europa - Dallas '12 NY Grand Prix. Endochondral ossification underlies the formation of the base of the skull , some bones of the face, the bones of the limbs and girdles, the vertebral column, the ribs, and the sternum. While all body muscle is mesoderm in origin, in the head neural crest may also contribute. The basic units of muscle are the contractile proteins actin and myosin arranged in sarcomeres. Sample Decks: Fetal Development, Molecular Embryology and Trunk Development, Histology - Pre-Embryonic - Reverse Show Class Histology. ... Introduction to Histology – Applications & Importance. However, factors that regulate these essential myogenic inducers remain poorly described. Muscular dystrophy involves a group of inherited muscle diseases that cause progressive muscular atrophy and weakness. We also review satellite cell quiescence and activation that govern muscle regeneration and repair (Section 3). Malformation of the hands and feet is known as cleft hand and cleft foot, which consist of an abnormal cleft between the second and fourth metacarpal or metatarsal bones and soft tissues. During the sixth gestational week, joints begin to develop with the formation of condensed mesenchyme in the interzone, the region between two bone primordia. Chondrification involves the condensation and differentiation of mesenchymal cells into chondrocytes (cartilage cells). At 29 weeks, type I fibers are visible, and by … • There are 3 types of muscle (skeletal, cardiac and smooth). Myoblasts fuse to form elongated, multinucleated, and cylindrical muscle fibers. 2012 IFBB Desert Muscle '12 Flex Pro '12 Australian Pro '12 NPC NJ Suburban. As development continues, the notochord completely degenerates in the centrum, but where it persists, it enlarges as a gelatinous center. Concurrently, blood vessels invade the diaphysis. Chondrification occurs while the sternal bars migrate medially. Klippel-Feil syndrome involves the fusion of cervical vertebrae, which results in reduced mobility, short neck, and low hairline. By the sixth gestational week, these chondrocytes differentiate into hyaline cartilage models, foreshadowing the prospective bones. Malformations of digits include brachydactyly, syndactyly, polydactyly, and ectrodactyly. Plantaris and soleus muscles were removed from animals which had not been tested physiologically and were embedded in OCT compound at -200. Ossification of the vertebrae begins at the seventh gestational week, but only ends during the second decade of adulthood. Histology of muscle Muscle function: 1. contraction for locomotion and skeletal movement 2. contraction for propulsion 3. contraction for pressure regulation Muscle classification: muscle tissue may be classified according to a morphological classification or a functional classification. costochondral joints) or fibrocartilage (i.e. MH 017 Stratified Squamous Epithelia. Ju B(1), Chong SW, He J, Wang X, Xu Y, Wan H, Tong Y, Yan T, Korzh V, Gong Z. A mild form of the disease, Baker muscle development, is associated with a reduced size and/or abundance. They consist of a core of mesenchymal cells - derived from the somatic layer of the lateral plate mesoderm - covered by a layer of ectoderm. Brachydactyly involves shortened digits. The ovary is a rounded body approx. Cite this page: Hill, M.A. Not all cells in the caudal half of each sclerotome undergo resegmentation. Later, a second circular constriction separates the proximal portion into two additional segments; the familiar parts of the limbs thus become recognizable. Although different, the occurrence of both processes first require the condensation of mesenchymal cells - the loosely organized embryonic connective tissue. At puberty, five secondary ossification centers appear in the vertebrae: one at the tip of the spinous process, one at the tip of each transverse process, and one on both the superior and inferior rim of the vertebral body. LM. While the process of forming these cartilage models is initiated, synovial joints form between the two chondrifying bone primordia at the interzone. Fibroblasts form the epimysium and perimysium layers of the muscle, whereas the external lamina and reticular fibers form the endomysium. Histology Learning System Appendix. Musculoskeletal anatomy is fascinating since it gives us insights as to how our body utilizes our muscles, bones, and joints to give us the ability to navigate in the world. This page describes skeletal muscle development, descriptions of cardiac muscle and smooth muscle development can be found in other notes. During or after fusion, myofilaments and myofibrils develop in the cytoplasm. Introduction to the musculoskeletal system, petrous part of the temporal bones and the adjacent parts of the occipital bone, Lamina of the vertebral arch (cranial view) - Liene Znotina, Transverse process (cranial view) - Liene Znotina. It is derived from two sources: the paraxial mesoderm and the neural crest cells. The appendicular skeleton includes the bones of the limbs and girdles. Instead, some migrate cranially and contribute to the formation of the intervertebral disc. Kim Bengochea, Regis University, Denver, Author: Development of the skeletal muscle involves the differentiation of myotome cells into myoblasts. IFBB North Americans '12 Houston Pro/Texas St. The sternum develops as two independent bands of mesenchymal cells before fusing and ossifying as one. sutures of the skull). By the sixth gestational week, the sclerotome cells surrounding the neural tube form a cartilaginous vertebral arch, and fuse with the cartilaginous vertebral body. Development of the limbs involves the inductive influences of the apical ectodermal ridge, the formation of circular constrictions to separate parts of the limbs, and opposite rotations of the upper and lower limbs. There are 3 main different types of muscle: skeletal, cardiac and smooth. Histology Guide - a virtual histology laboratory with zoomable images of microscope slides and electron micrographs. Summary This study describes the capillary supply of individual regenerating muscle fiber during three stages of its development. THE OVARY. Recapitulation of fast skeletal muscle development in zebrafish by transgenic expression of GFP under the mylz2 promoter. Both congenital deformities are often asymptomatic, but may impair cardiac and respiratory function depending on the severity. Structures derived from the chondrocranium include components of the occipital bone, the sphenoid bone, and the ethmoid bone, specifically the: The viscerocranium is mainly formed by the first two pharyngeal arches. Within a skeletal muscle cell, the numerous myofibrils are separated by glycogen, mitochondria, and muscle triads (two terminal cisternae and a T tubule) and other organelles. 2012 IFBB California '12 Europa Show '12 Arnold '12 Ronnie Coleman '12 NPC Steve Stone '12 Natural Ohio. Descriptions of their development, structure and histology can be found on various System and Histology pages on this site. Polydactyly involves the presence of extra digits. Muscle development and growth were investigated in diploid populations of normal-sex-ratio and all-female Atlantic salmon (Salmo salarL.) Malformations of skeletal muscle can result in certain conditions such as Poland sequence, prune belly syndrome and muscular dystrophy. Francesca Salvador MSc Only after birth, secondary ossification centers develop in the epiphyses, which will also undergo the same ossification and vascularization processes that took place in the diaphysis. While all body muscle is mesoderm in origin, in the head neural crest may also contribute. Type 1 fibers were smaller than type 2 fi … Cleft sternum is the result of a complete or partial midline fusion of the sternal bars. Endochondral ossification thus begins from these primary ossification centers at the diaphysis and proceeds toward the epiphyses. Cells in the dorsal part form the dermatome and two edges, the ventrolateral lip and the dorsomedial lip. In other words, the base of the skull, some bones of the face, the vertebral column, the ribs, the sternum, and the bones of the limbs and girdles form by a two-step process: chondrification and ossification. In the lumbar region, the costal processes of the first sacral vertebrae fuse and form the lateral sacral mass, known as the ala of the sacrum. “I would honestly say that Kenhub cut my study time in half.” The first pharyngeal arch undergoes intramembranous ossification to give rise to the: The dorsal tip of the mandibular process and the second pharyngeal arch undergo endochondral ossification to give rise to the malleus, the incus, and the stapes. Malformations of the sternum include cleft sternum, pectus excavatum, and pectus carinatum. ABSTRACT Myosin heavy chain-embryonic (MyHC-emb) is a skeletal muscle-specific contractile protein expressed during muscle development. As the limbs continue to grow, cells farther from the influence of the AER begin to differentiate into cartilage and muscle. The first seven pairs of ribs attach to the sternum through their own cartilages. While the external shape of the limbs becomes established, the bones of the limbs and girdles (with the exception of the clavicle) form by a two-step process: chondrification and endochondral ossification. Malformations of the skull include cranioschisis and craniosynostosis. Spina bifida involves the failure of vertebral arches to fuse, thus generally exposing the spinal cord in the sacral region. Learn skeletal muscle histology with free interactive flashcards. Similar to the membranous neurocranium, the cartilaginous neurocranium is derived from the same sources. Bone formation can occur either by intramembranous ossification or endochondral ossification. Further cell death in the interdigital spaces are what creates the separation of the digits. The formation of these structures begin by the end of the fourth gestational week, where limb buds become visible as outpocketings from the ventrolateral body wall. Representative histology sections of the m. Semitendinosus for the two breeds of cattle were analysed at each time point (data not shown). Combined, these two structures form the intervertebral discs. Smooth muscle appears undulating only when it has been contracted (naturally or artifactually) to less than its initial length. Malformations of the vertebra include Klippel-Feil sequence and spina bifida. By the tenth gestational week , they fuse in cranial-to-caudal sequence at the midline and form the cartilage model of the manubrium, the sternal body, and the xiphoid process. From this point on, there are two ways osteogenesis can occur: intramembranous ossification and endochondral ossification. Dystrophin is the product of genes affected in Duchenne muscle development, a fatal disorder that develops when a mutation of a gene leads to the absence of a protein. Premature closure of the sagittal suture can result in a long and narrow skull due to frontal and occipital expansions. Cranioschisis involves the failure of the cranial vault to form, thus exposing the brain tissue to amniotic fluid, resulting in anencephaly. and their triploid counterparts produced by high-pressure treatment. HAMSTER MUSCLE DEVELOPMENT 43 Histology and Histochemistry. Pectus carinatum (keel-shaped chest) involves an anterior projecting sternum. Author information: (1)Department of Biological Sciences, National University of Singapore, Singapore. It initially consists of a number of separate cartilages that eventually fuse together. The AER exerts an inductive influence on the core of mesenchymal cells to remain undifferentiated and to rapidly proliferate; this region is known as the progress zone. Sclerotomes form the vertebra and the ribs, whereas myotomes form the majority of the muscular system. Our engaging videos, interactive quizzes, in-depth articles and HD atlas are here to get you top results faster. Further formation of fingers and toes depends on three factors: their continued outgrowth under the influence of the AER, mesenchymal condensation to form cartilaginous digital rays, and apoptosis of intervening tissue between the rays. Lecture presentation about the structure of skeletal muscle tissue recorded by Dr. Michael Sliman in Spring 2015 as an overview of the Muscular Tissue. The cartilaginous part of the neurocranium forms the base of the skull. Dr Muthoka/Mr. Skin and Esophagus. At birth, the membranous bones are separated from each other by dense connective tissue membranes that form fibrous joints, known as the cranial sutures (coronal, sagittal, and lambdoid). Histology Of The Cardiac Muscle Ine PPT. Perimysium surrounds compacted and grouped fibers by 24 weeks, and utrophin disappears, whereas dystrophin stains intensely. Skeletal muscle is derived from the mesoderm. This page was last modified on 3 May 2012, at 14:17. https://embryology.med.unsw.edu.au/embryology/index.php/Muscle_Development, https://embryology.med.unsw.edu.au/embryology/index.php?title=Muscle_Development&oldid=91166. Mesenchymal cells from these two sources surround the brain at various sites, form primary ossification centers, and undergo intramembranous ossification. A remarkably distinct repertoire of genes and ontological features characterise this tissue, and recent evidence has shown that skeletal muscles of the head, the craniofacial muscles, are evolutionarily, morphologically and molecularly distinct from those of the trunk. and grab your free ultimate anatomy study guide! Thus, each vertebra develops from two adjacent sclerotomes rather than from one sclerotome. This results in the recruitment of osteoblasts, the differentiation of certain invading cells into hematopoietic cells (blood cells of the bone marrow), and the restriction of proliferating chondrocytes towards the distal ends of the cartilage model (epiphyses). Ectrodactyly involves the absence of a digit. As the brain and the skull continue to grow after birth, many of these sutures and fontanelles will remain membranous and open postnatally. Reviewer: 2012 IFBB St. Louis Pro. This forms the nucleus pulposus, which is later surrounded by circularly arranged fibers known as the annulus fibrosis. Sequentially, the dense fibrous tissue forms the articular cartilage that covers the ends of the adjacent bone primordia. The process in which mesenchymal cells ensheathed in membranous tissue directly undergo ossification is known as intramembranous ossification. Learning anatomy is a massive undertaking, and we're here to help you pass with flying colours. In spina bifida occulta, there are minimal neurological deficits; the spinal cord is intact and is covered by skin. It is a thick smooth muscle layer that expands during pregnancy and serves to protect and expel the fetus. Meanwhile, the terminal portion becomes flattened to form the handplates and footplates. Recall that the paraxial mesoderm forms segmented series of tissue blocks on each side of the neural tube, the somites. – The membranous part of the neurocranium forms the calvaria (skullcap). The original site where the costal process is connected to the vertebra becomes replaced by costovertebral synovial joints. (2021, January 12) Embryology Muscle Development. 2021 The vertebral column develops from the sclerotomes, the ventromedial part of the somite. Skeletal muscle forms by fusion of mononucleated myoblasts to … Before developing into skeletal muscles, myotome cells first differentiate into myoblasts (embryonic muscle cells) through elongation of their nuclei and cell bodies. In limbs, myoblasts migrate to the limb buds and surround the primordial limb bones. Histology of Cardiac Muscle: The cardiac muscle fibres are separated from each other by the connective tissue endomysium along with blood vessels and lymphatics. V. Development of body musculature Derived from paraxial mesoderm (somitomeres in head, somites in neck and trunk) Somite gives rise to sclerotome , which develops into vertebral and rib bones; myotome , which develops into muscle, and dermatome , which develops into dermal connective tissue. Kenhub. Histology, also known as microscopic anatomy or microanatomy, is the branch of biology which studies the microscopic anatomy of biological tissues. Descriptions of their development, structure and histology can be found on various System and Histology pages on this site. The structural development of the upper limbs and lower limbs are similar but with two exceptions: the development of the lower limb is approximately 1 to 2 days behind that of the upper limb, whereas the upper and lower limbs rotate in opposite directions. The sternum develops from a pair of separate vertical, condensed bands of mesenchymal cells, known as the sternal bars. Somites were formed at the rate of 6h−1 in both diploids and triploids at 6°C. The skull consists of a neurocranium and a viscerocranium, with each having membranous and cartilaginous components. The spinous, transverse, and costal processes develop as extensions from this newly assembled cartilage model. The bones that make up the vertebral column, the ribs, and sternum form only by endochondral ossification. Pectus excavatum (hollow chest) involves a concave depression of the sternum. This results in the formation of membranous flat bones that are characterized by needle-like bone spicules. Generally, the posterior fontanelle closes first by 2 months of age, the mastoid fontanelle by 6 months, the anterior fontanelle by 18 months, and the cranial sutures by 36 months. Choose from 500 different sets of skeletal muscle histology flashcards on Quizlet. They are cartilaginous during the embryonic period and undergo ossification during the fetal period. Collectively, these structures form the dermomyotome. The process in which mesenchymal cells first differentiate into cartilage models before undergoing ossification is known as endochondral ossification. Cells in the ventromedial part of the somite form the sclerotome. The neural crest cells form the prechordal chondrocranium anterior to the center of the sella turcica, whereas the paraxial mesoderm form the chordal chondrocranium posterior to the center of the sella turcica. Register now The cardiac muscle fibres are not made up of one straight simple cylinder but they have got short cylindrical branches in all directions (in any dimension). The development of synovial joints involves a more extensive process: the central mesenchymal cells in the interzone undergo apoptosis to form the synovial joint cavities, whereas the peripheral cells differentiate into ligaments and dense fibrous tissue. Structures derived from the membranous neurocranium include the parietal bones, part of the temporal bones, and the occipital bone. The subsequent five pairs of ribs attach to the sternum through the cartilage of the seventh rib. Reading time: 21 minutes. The first stage of any type of bone formation involves a mesenchymal condensation, where cells become densely packed together. While many of the loci involved are already known, these conditions remain incurable, and genetic models are being developed in an effort to understand the pathological mechanisms involved. Both the neurocranium and the viscerocranium have distinct components that are formed either by intramembranous ossification or endochondral ossification. The rate of fiber growth varied with age, muscle, and fiber type. By the end of the eight week, digit separation is complete while the fingers develop distal swellings known as tactile pads, which are what create patterns for fingerprints. Sample Decks: CT and Epithelial, Muscle And Nervous, Cardiac Show Class Histology. Grounded on academic literature and research, validated by experts, and trusted by more than 1 million users. Histology Flashcard Maker: Adams Bruce Al-os. Premature closure of the coronal suture can result in a short skull. Large muscle fibers (Wohlfart B) are visible by 20-21 weeks, Wohlfart A by 21-25 weeks. The muscular dystrophies and congenital myopathies are inherited diseases of the skeletal muscle, which lead to a loss of muscle function and are often fatal. The heart and its major vessels are covered only by skin and soft tissue and thus are unprotected. Each sclerotome then undergoes resegmentation, a process that involves the caudal half of each sclerotome to fuse with the cranial half of each adjacent sclerotome; this forms the centrum, the primordial vertebral body. Read more. Chapter 4 - Muscle Tissue. The rostral-to-caudal development of Last reviewed: October 20, 2020 Biceps brachii muscle (histology slide of fetal elbow) Joints are classified as: The development of fibrous joints involves mesenchymal cells in the interzone to differentiate into dense fibrous tissue (i.e. The musculoskeletal system develops from three sources: The development of bone and muscle begins at the fourth gestational week, when the paraxial mesoderm differentiates into somites; the latter gives rise to sclerotomes and dermomyotomes. The vertebral column develops from a resegmentation process of the somites, while the ribs develop as extensions from the thoracic vertebrae. Malformations of the ribs include accessory ribs and fused ribs. Myogenesis is the formation of muscular tissue, particularly during embryonic development. On the other hand, the lower limbs rotate 90° medially, placing the extensor muscles on the anterior surface and the big toe medially. Prune belly syndrome involves the partial or complete absence of abdominal muscles; this results with a very thin abdominal wall, making the internal organs visible and easy to palpate. Syndactyly involves the fusion of two or more digits. As such, premature unilateral closure of sutures can result in an asymmetrical skull. At the distal border of the limb, the ectoderm forms the apical ectodermal ridge (AER). Ojora Wednesday 2.00-5.00 pm Embryology: Development of limbs and muscle-Dr Muthoka WEEK 11 (14 th-18 th March 2016) DAY TIME TOPIC Monday 9.00-10.30 am CONTINUOUS ASSESSMENT 2-Dr Muthoka/Mr. Bone spicules progressively radiate from the primary ossification centers toward the periphery. Cardiac and smooth muscle tissues develop from local populations of mesenchymal cells (splanchnic mesoderm), while skeletal muscles develop from mesoderm within the somites. The process of chondrification continues until a cartilaginous vertebral column is fully formed. This current page is a bookmark for muscle development related pages. Histology Flashcard Maker: Connor Schmidt. The remaining mesenchymal cells surrounding the interzone differentiate into chondrocytes to form the joint capsules and the synovial membrane. In spina bifida cystica, the meninges and/or the neural tissue protrude through the skin at the sacral region to form a cyst-like sac. In early embryonic development, these myoblasts proliferate if enough fibroblast growth factor (FGF) is present. In contrast, the clavicle is a membrane bone: it forms directly by intramembranous ossification. Continued proliferation of the chondrocytes in the growth plate is what allows the diaphysis to lengthen and thus what maintains the growth of bones. If this article peaks your interest, you probably have a solid foundation in this topic and are ready to take your knowledge to the next level. Chondrocytes ( cartilage cells ) the cartilage of the neurocranium forms the apical ectodermal (. 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It is a bookmark for muscle development, structure and histology pages on this site the remaining mesenchymal cells in. Malformation of the seventh cervical vertebrae, which is later surrounded by circularly arranged known.: ( 1 ) Department of Biological Sciences, National University of,... Of epiphyseal cartilage plate, persists between the epiphyses and the synovial membrane,. Tissues are a prerequisite for healthy meat-producing animals of GFP under the promoter! Skull continue to grow, cells farther from the sclerotomes, the portion... Page was last modified on 3 may 2012, at 14:17. https //embryology.med.unsw.edu.au/embryology/index.php/Muscle_Development! Of myoblasts into multi-nucleated fibers called myotubes but only ends during the embryonic period either by ossification... Can occur: intramembranous ossification underlies the formation of membranous flat bones that make up the vertebral,. Limb buds and surround the brain and the floating ribs suture can result in a cyclic in... Cells first differentiate into hyaline cartilage models, foreshadowing the prospective bones by a set...